Spatial mapping of cellular senescence: emerging challenges and opportunities

Affiliations

• ¹ Aging Institute, University of Pittsburgh School of Medicine/UPMC and Division of Pulmonary, Allergy and Critical Care Medicine, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
• ² Buck Institute for Research on Aging, Novato, CA, USA.
• ³ Dorothy M. Davis Heart and Lung Research Institute, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, the Ohio State University, Columbus, OH, USA.
• ⁴ Department of Laboratory Medicine and Pathology, Department of Biochemistry, Molecular Biology and Biophysics, Department of Neuroscience and Institute on the Biology of Aging and Metabolism, Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA.
• ⁵ Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine and Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA.
• ⁶ Department of Physiology and Biomedical Engineering, Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
• ⁷ Department of Biomedical Engineering, Yale University, New Haven, CT, USA.
• ⁸ Stanford 1000 Immunomes Project, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
• ⁹ Instituto de Investigaciones en Medicina Traslacional (IIMT), Universidad Austral, Pilar, Argentina.
• ¹⁰ Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
• ¹¹ Columbia University Irving Medical Center and New York Genome Center, Columbia University, New York, NY, USA.
• ¹² The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
• ¹³ Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
• ¹⁴ Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
• ¹⁵ Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
• ¹⁶ Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
• ¹⁷ University of California, San Diego, CA, USA.
• ¹⁸ Department of Biochemistry, Institute for Protein Design and Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA, USA.
• ¹⁹ Department of Physiology and Biomedical Engineering, Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. passos.joao@mayo.edu.